Synonyms: 35 beta calcimedin,35-beta calcimedin,AIV,Annexin 4,Annexin A4,Annexin IV (placental anticoagulant protein II),Annexin IV,Annexin IV placental anticoagulant protein II,Annexin-4,AnnexinA4,AnnexinIV,ANX 4,ANX A4,ANX4,ANXA 4,ANXA4,ANXA4 protein,ANXA4,Carbohydrate binding protein P33/P41,Carbohydrate-binding protein p33/p41,Chromobindin 4,Chromobindin-4,Chromobindin4,DKFZp686H02120,Endonexin I,EndonexinI,Lipocortin IV,LipocortinIV,MGC75105,OTTHUMP00000160052,OTTHUMP00000202207,P32.5,P33/41,PAP II,PAP-II,PAPII,PIG 28,PIG28,Placental anticoagulant protein II,PP4 X,PP4-X,PP4X,Proliferation inducing gene 28,Proliferation inducing protein 28,Protein II,Xanx-4,ZAP 36,ZAP36
Background: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59 % identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene.