Synonyms: OTTHUMP00000020374,OTTHUMP00000020377,OTTHUMP00000020379,PRO1280,SU FU,SU(F)U,Su(fu),SUFU,SUFU negative regulator of hedgehog signaling,SUFU,SUFUH,SUFUXL,Suppressor of fused homolog (Drosophila),Suppressor of fused homolog
Background: The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.