Synonyms: Chondroitin sulfate proteoglycan core protein,Cytolytic granule proteoglycan core protein,FLJ12930,gp600,Hematopoetic proteoglycan core protein,Mastocytoma proteoglycan core protein,MGC9289,OTTHUMP00000019716,P.PG,PG19 core protein,Pgsg,Platelet proteoglycan core protein,platelet proteoglycan protein core,PLATELET PROTEOGLYCAN PROTEIN CORE,PPG,PPG,PRG,PRG1,PROTEOGLYCAN 1,proteoglycan 1,secretory granule,Proteoglycan 10K core protein,Proteoglycan peptide core protein,PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE,secretory granule proteoglycan 1,Secretory granule proteoglycan core peptide,Secretory granule proteoglycan core protein,Serglycin,serglycin proteoglycan,Sgc,Srgn,SRGN
Background: This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.