Synonyms: AMF,Aurocrine motility factor,Autocrine motility factor,DKFZp686C13233,EC 126.96.36.199,G6PI,Glucose phosphate isomerase,Glucose-6-phosphate isomerase,GNPI,GPI,Gpi1,Hexose monophosphate isomerase,Hexosephosphate isomerase,Neuroleukin,NLK,Oxoisomerase,PGI,PHI,Phosphoglucose isomerase,Phosphohexomutase,Phosphohexose isomerase,Phosphosaccharomutase,SA 36,SA-36,SA36,Sperm antigen 36
Background: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.