Synonyms: ATP dependent RNA helicase DDX5,DDX 5,Ddx5,DDX5,DEAD (Asp Glu Ala Asp) box helicase 5,DEAD (Asp Glu Ala Asp) box polypeptide 5,DEAD box 5,DEAD box protein 5,DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase,68kD),G17P1,HELR,HLR1,HUMP68,P68,p68 RNA helicase,Probable ATP dependent RNA helicase DDX5,Probable ATP-dependent RNA helicase DDX5,RNA helicase p68
Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. Alternative splicing results in multiple transcript variants.