MICA Antikörper (MHC Class I Polypeptide-Related Sequence A)

Details for Product anti-MICA Antibody No. ABIN6567599
Target
Reaktivität
Human, Maus
89
18
14
11
7
6
2
1
Wirt
Kaninchen
50
37
Klonalität
Polyklonal
Konjugat
Dieser MICA Antikörper ist unkonjugiert
8
7
5
2
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
64
46
38
29
24
15
13
9
7
6
5
5
5
4
1
1
1
1
Optionen
Immunogen Recombinant protein of human MICA
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MICA (MICA Antibody Abstract)
Hintergrund

Synonyms: HLA class I antigen,FLJ36918,FLJ60820,MGC111087,MGC21250,MHC class I chain related gene A protein,MHC class I chain related protein A,MHC class I chain related protein A HLA B HLA C,MHC class I polypeptide related sequence A,MHC class I polypeptide-related sequence A,MHC class I related protein,MIC A,MIC-A,micA,MICA,OTTHUMP00000029088,OTTHUMP00000044528,OTTHUMP00000165170,OTTHUMP00000165172,PERB11.1,Stress inducible class I homolog

Background: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

Molekulargewicht

Observed_MW: 50kDa

Calculated_MW: 31kDa/42kDa

Gen-ID 100507436
UniProt Q29983
Pathways Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (ABIN6567599) Immunohistochemistry of paraffin-embedded human stomach using MICA antibody.
Image no. 2 for anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (ABIN6567599) Western blot analysis of extracts of various cell lines, using MICA Antibody.