WISP2 Antikörper (WNT1 Inducible Signaling Pathway Protein 2)

Details for Product anti-WISP2 Antibody No. ABIN6567546
Target
Reaktivität
Human, Maus, Ratte
55
4
4
1
1
1
Wirt
Kaninchen
49
8
Klonalität
Polyklonal
Konjugat
Dieser WISP2 Antikörper ist unkonjugiert
6
3
3
3
3
2
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC)
48
31
10
5
4
4
3
1
1
1
1
Optionen
Immunogen Recombinant protein of human WISP2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung WISP2 (WISP2 Antibody Abstract)
Hintergrund

Synonyms: CCN family member 5,CCN5,Connective tissue growth factor like protein,Connective tissue growth factor related protein 58,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGF L,CTGF-L,WISP 2,WISP-2,Wisp2,WISP2,Wnt 1 signaling pathway protein 2,WNT1 inducible signaling pathway protein 2,WNT1-inducible-signaling pathway protein 2

Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Molekulargewicht

Observed_MW: Refer to figures

Calculated_MW: 22kDa/26kDa

Gen-ID 8839
UniProt O76076
Pathways Growth Factor Binding
Applikations-hinweise IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-WNT1 Inducible Signaling Pathway Protein 2 (WISP2) antibody (ABIN6567546) Immunohistochemistry of paraffin-embedded human esophagus using WISP2 antibody.
Image no. 2 for anti-WNT1 Inducible Signaling Pathway Protein 2 (WISP2) antibody (ABIN6567546) Immunohistochemistry of paraffin-embedded mouse brain using WISP2 antibody.