Synonyms: Cementoin,ELAF,Elafin,Elastase Specific Inhibitor,Elastase-specific inhibitor,ES 1,ESI,Peptidase inhibitor 3,Peptidase inhibitor 3, skin derived,PI 3,PI-3,PI3,Pre elafin,Protease inhibitor 3 skin derived ,Protease inhibitor 3, skin derived (SKALP),Protease inhibitor WAP3,SKALP,Skin derived Anti leukoproteinase,Skin-derived antileukoproteinase,Trappin 2,WAP four disulfide core domain 14,WAP four disulfide core domain protein 14,WAP four-disulfide core domain protein 14,WAP3,WFDC14
Background: This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.