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MLL/KMT2A Antikörper

MLL Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6567425
  • Target Alle MLL/KMT2A (MLL) Antikörper anzeigen
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Reaktivität
    • 31
    • 12
    • 9
    Human
    Wirt
    • 26
    • 5
    Kaninchen
    Klonalität
    • 27
    • 4
    Polyklonal
    Konjugat
    • 19
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLL/KMT2A Antikörper ist unkonjugiert
    Applikation
    • 17
    • 14
    • 14
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant protein of human KMT2A
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB 1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Andere Bezeichnung
    KMT2A (MLL Produkte)
    Synonyme
    ALL-1 antikoerper, CXXC7 antikoerper, HRX antikoerper, HTRX1 antikoerper, MLL antikoerper, MLL/GAS7 antikoerper, MLL1A antikoerper, TET1-MLL antikoerper, TRX1 antikoerper, WDSTS antikoerper, 6430520K01 antikoerper, All1 antikoerper, Cxxc7 antikoerper, Mll antikoerper, Mll1 antikoerper, mKIAA4050 antikoerper, lysine methyltransferase 2A antikoerper, lysine (K)-specific methyltransferase 2A antikoerper, KMT2A antikoerper, Kmt2a antikoerper
    Hintergrund

    Synonyms: ALL-1,ALL1,C-terminal cleavage product of 180 kDa,CXXC-type zinc finger protein 7,CXXC7,HRX,HTRX1,KMT2A,Lysine N-methyltransferase 2A,Mll,MLL cleavage product C180,MLL1,MLL1,MLL1A,N-terminal cleavage product of 320 kDa,p180,p320,Trithorax-like protein,TRX1,Zinc finger protein HRX

    Background: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

    Molekulargewicht

    Observed_MW: 190kDa

    Calculated_MW: 427kDa/431kDa/432kDa

    Gen-ID
    4297
    UniProt
    Q03164
    Pathways
    Warburg Effekt
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