Tropomyosin 1 (Alpha) (TPM1) Antikörper

Details zu Produkt Nr. ABIN6567177
Target
Reaktivität
Human, Maus, Zebrafisch (Danio rerio)
57
43
36
20
6
4
4
3
2
2
2
1
1
1
1
Wirt
Kaninchen
47
21
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
3
3
2
2
2
2
2
2
2
2
Applikation
Immunofluorescence (IF), Western Blotting (WB)
43
21
17
12
8
7
5
3
2
2
1
1
Optionen
Immunogen Recombinant protein of human TPM1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung TPM1 (TPM1 Antibody Abstract)
Hintergrund

Synonyms: AA986836,AI854628,Alpha tropomyosin,alpha-TM,Alpha-tropomyosin,C15orf13,cardiomyopathy,hypertrophic 3,CMD1Y,CMH3,HTM alpha,HTM-alpha,OTTHUMP00000163688,sarcomeric tropomyosin kappa,TM2,Tmpa,TMSA,Tpm-1,TPM1,TPM1,tropomyosin 1 (alpha),tropomyosin 1 (alpha) isoform 1,tropomyosin 1 (alpha) isoform 2,tropomyosin 1 (alpha) isoform 3,tropomyosin 1 (alpha) isoform 4,tropomyosin 1 (alpha) isoform 5,tropomyosin 1 (alpha) isoform 6,tropomyosin 1 (alpha) isoform 7,Tropomyosin 1,Tropomyosin alpha 1 chain,Tropomyosin alpha-1 chain,Tropomyosin,skeletal muscle alpha,Tropomyosin-1

Background: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Molekulargewicht

Observed_MW: 36kDa

Calculated_MW: 26kDa/28kDa/32kDa

Gen-ID 7168
UniProt P09493
Pathways Regulation of Actin Filament Polymerization
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Tropomyosin 1 (Alpha) (TPM1) antibody (ABIN6567177) Immunofluorescence analysis of HeLa cells using TPM1 antibody.
Image no. 2 for anti-Tropomyosin 1 (Alpha) (TPM1) antibody (ABIN6567177) Western blot analysis of extracts of various cell lines, using TPM1 antibody.