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BRCA1 Antikörper

BRCA1 Reaktivität: Human, Ratte, Maus IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6567052
  • Target Alle BRCA1 Antikörper anzeigen
    BRCA1 (Breast Cancer 1 (BRCA1))
    Reaktivität
    • 193
    • 36
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 162
    • 37
    • 2
    Kaninchen
    Klonalität
    • 166
    • 35
    Polyklonal
    Konjugat
    • 94
    • 18
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser BRCA1 Antikörper ist unkonjugiert
    Applikation
    • 127
    • 67
    • 42
    • 42
    • 41
    • 37
    • 29
    • 24
    • 22
    • 12
    • 12
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human BRCA1 (NP_009230.2).
    Isotyp
    IgG
    Top Product
    Discover our top product BRCA1 Primärantikörper
  • Applikationshinweise
    IF 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    BRCA1 (Breast Cancer 1 (BRCA1))
    Andere Bezeichnung
    BRCA1 (BRCA1 Produkte)
    Synonyme
    BRCAI antikoerper, BRCC1 antikoerper, BROVCA1 antikoerper, IRIS antikoerper, PNCA4 antikoerper, PPP1R53 antikoerper, PSCP antikoerper, RNF53 antikoerper, iris antikoerper, pscp antikoerper, brcai antikoerper, brcc1 antikoerper, rnf53 antikoerper, brca1 antikoerper, BRCA1 antikoerper, LOC100224649 antikoerper, BRCA1, DNA repair associated antikoerper, breast cancer 1 antikoerper, breast cancer 1, early onset antikoerper, breast cancer 1 L homeolog antikoerper, BRCA1 antikoerper, brca1 antikoerper, LOC755086 antikoerper, Brca1 antikoerper, brca1.L antikoerper
    Hintergrund
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
    Molekulargewicht

    Observed_MW: 280kDa

    Calculated_MW: 7kDa/78-85kDa/202-210kDa

    Gen-ID
    672
    UniProt
    P38398
    Pathways
    Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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