MCM3 Antikörper (Minichromosome Maintenance Complex Component 3)

Details for Product anti-MCM3 Antibody No. ABIN6567003
Target
Reaktivität
Human, Affe, Maus
96
48
44
7
5
4
4
4
3
2
1
1
1
1
Wirt
Kaninchen
84
12
1
Klonalität
Polyklonal
Konjugat
Dieser MCM3 Antikörper ist unkonjugiert
7
5
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
74
36
26
18
14
14
7
5
5
4
2
2
1
1
1
Optionen
Immunogen Recombinant protein of human MCM3
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MCM3 (MCM3 Antibody Abstract)
Hintergrund

Synonyms: Cervical cancer proto oncogene 5,DNA polymerase alpha holoenzyme associated P1,DNA polymerase alpha holoenzyme associated protein P1,DNA polymerase alpha holoenzyme-associated protein P1,DNA replication factor MCM3,DNA replication licensing factor mcm3,HCC 5,HCC5,hRlf beta subunit,Human cervical cancer proto oncogene 5,MCM 3,mcm3,MCM3 minichromosome maintenance deficient 3,MCM3,MGC1157,Minichromosome maintenance complex component 3,Minichromosome maintenance deficient 3,Minichromosome maintenance protein 3,P1 h,P1 MCM3,P1 Protein,P1-MCM3,P1.h,p102,P102 protein,Replication licensing factor beta subunit,RLF beta subunit,RLF subunit beta,RLFB

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 115kDa

Calculated_MW: 90kDa/95kDa

Gen-ID 4172
UniProt P25205
Pathways DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Minichromosome Maintenance Complex Component 3 (MCM3) antibody (ABIN6567003) Immunohistochemistry of paraffin-embedded human oophoroma using MCM3 antibody.
Image no. 2 for anti-Minichromosome Maintenance Complex Component 3 (MCM3) antibody (ABIN6567003) Immunofluorescence analysis of U2OS cells using MCM3 antibody.
Image no. 3 for anti-Minichromosome Maintenance Complex Component 3 (MCM3) antibody (ABIN6567003) Western blot analysis of extracts of various cell lines, using MCM3 antibody.