Synonyms: MGC10182,Neural crest transcription factor Slug,Protein snail homolog 2,Slug (chicken homolog) zinc finger protein,Slug homolog zinc finger protein,Slug zinc finger protein,SLUGH,SLUGH 1,SLUGH1,SNAI 2,Snai2,SNAI2,Snail 2,Snail homolog 2,Snail2,WS 2D,WS2D,Zinc finger protein SLUG,Zinc finger protein SNAI2
Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.