Synonyms: Calcium dependent phospholipid binding protein,CPLA 2,cPLA2 alpha,cPLA2,Cytosolic phospholipase A2,Cytosolic phospholipase A2 group IVA,Lysophospholipase,MGC126350,PA24A,Phosphatidylcholine 2 acylhydrolase,Phosphatidylcholine 2-acylhydrolase,Phospholipase A2 group 4 A,Phospholipase A2 group IVA (cytosolic calcium dependent),Phospholipase A2 group IVA,PhospholipaseA2,PLA2G4,pla2g4a
Background: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.