Synonyms: AL713991.1,HGNC:9995,MGC17173,OTTMUSP00000022853,OTTMUSP00000022854,Regulator of G protein signalling 13,Regulator of G-protein signaling 13,RGD1562103,RGS 13,RGS13,RGS13,RP11 92K2.1
Background: The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.