Synonyms: NAD dependent deacetylase sirtuin 7,NAD dependent protein deacetylase sirtuin 7,NAD-dependent protein deacetylase sirtuin-7,Regulatory protein SIR2 homolog 7,Silent mating type information regulation 2 homolog,Silent mating type information regulation 2 S.cerevisiae homolog 7,SIR2 L7,SIR2 like protein 7,Sir2 related protein type 7,SIR2,S.CEREVISIAE,HOMOLOG-LIKE 7,SIR2-like protein 7,SIR2L 7,SIR2L7,SIR7,SIRT 7,SIRT7,Sirtuin 7,Sirtuin type 7,Sirtuin7
Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.