RAN Antikörper (RAN, Member RAS Oncogene Family)

Details for Product anti-RAN Antibody No. ABIN6566716
Target
Reaktivität
Human, Affe, Maus
86
55
42
7
6
5
5
4
3
3
3
3
2
2
2
1
1
1
Wirt
Kaninchen
66
14
6
Klonalität
Polyklonal
Konjugat
Dieser RAN Antikörper ist unkonjugiert
6
5
5
4
4
4
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
73
44
34
22
13
10
9
8
7
1
1
1
1
Optionen
Immunogen Recombinant protein of human RAN
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung RAN (RAN Antibody Abstract)
Hintergrund

Synonyms: Androgen receptor associated protein 24,Androgen receptor-associated protein 24,ARA 24,ARA24,Gsp1,GTP binding nuclear protein RAN,GTP-binding nuclear protein Ran,GTPase Ran,Guanosine triphosphatase Ran,LPS,OK/SW-cl.81,ran,RAN member RAS oncogene family,RAN,RanGTPase,Ras like protein TC4,Ras related nuclear protein,Ras-like protein TC4,Ras-related nuclear protein,RASL2 8,TC 4,TC4

Background: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Molekulargewicht

Observed_MW: 23kDa

Calculated_MW: 24kDa

Gen-ID 5901
UniProt P62826
Pathways Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-RAN, Member RAS Oncogene Family (RAN) antibody (ABIN6566716) Western blot analysis of extracts of various cell lines, using RAN antibody.
Image no. 2 for anti-RAN, Member RAS Oncogene Family (RAN) antibody (ABIN6566716) Immunofluorescence analysis of HeLa cells using RAN antibody.