MUC1 Antikörper

Produktnummer ABIN6566576

Produktdetails anti-MUC1 Antikörper

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human MUC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000 - 1:3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC1 (MUC1 Produkte)

Synonyme: CA 15-3 antikoerper, CD227 antikoerper, EMA antikoerper, H23AG antikoerper, KL-6 antikoerper, MAM6 antikoerper, MCKD1 antikoerper, MUC-1 antikoerper, MUC-1/SEC antikoerper, MUC-1/X antikoerper, MUC1/ZD antikoerper, PEM antikoerper, PEMT antikoerper, PUM antikoerper, Muc-1 antikoerper, mucin 1, cell surface associated antikoerper, mucin 1, transmembrane antikoerper, MUC1 antikoerper, Muc1 antikoerper

Hintergrund:

Synonyms: ADMCKD,ADMCKD1,Breast carcinoma associated antigen DF3,Breast carcinoma-associated antigen DF3,CA 15-3,CA15 3,CA15 3 antigen,CA15.3,Cancer antigen 15-3,Carcinoma associated mucin,Carcinoma-associated mucin,CD 227,CD227,DF3 antigen,EMA,Episialin,H23 antigen,H23AG,KL 6,KL-6,KL6,Krebs von den Lungen-6,MAM 6,MAM6,MCD,MCKD,MCKD1,Medullary cystic kidney disease 1 (autosomal dominant),Medullary cystic kidney disease,autosomal dominant,MUC 1,MUC-1,MUC-1/SEC,MUC-1/X,MUC1,MUC1-alpha,MUC1-beta,MUC1-CT,MUC1-NT,MUC1/ZD,MUC1,Mucin 1,Mucin 1 transmembrane,Mucin 1,cell surface associated,Mucin-1 subunit beta,Peanut reactive urinary mucin,Peanut-reactive urinary mucin,PEM,PEMT,Polymorphic epithelial mucin,PUM,Tumor associated epithelial membrane antigen,Tumor associated epithelial mucin,Tumor associated mucin,Tumor-associated epithelial membrane antigen,Tumor-associated mucin

Background: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Molekulargewicht:

Observed_MW: 122kDa

Calculated_MW: 10-29kDa/103kDa/121-122kDa

Gen-ID: 4582

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling