Synonyms: Activating transcription factor 4,ATF 4,ATF4,ATF4 protein,ATF4,cAMP-dependent transcription factor ATF-4,cAMP-responsive element-binding protein 2,CREB 2,CREB-2,CREB2,Cyclic AMP dependent transcription factor ATF 4,Cyclic AMP response element binding protein 2,Cyclic AMP-dependent transcription factor ATF-4,Cyclic AMP-responsive element-binding protein 2,DNA binding protein TAXREB67,DNA-binding protein TAXREB67,Tax Responsive Enhancer Element B67,Tax-responsive enhancer element-binding protein 67,TaxREB67,TXREB
Background: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.