LRP5 Antikörper (Low Density Lipoprotein Receptor-Related Protein 5)

Details for Product anti-LRP5 Antibody No. ABIN6566477
Target
Reaktivität
Human, Maus, Ratte
84
77
44
1
1
Wirt
Kaninchen
90
7
6
1
Klonalität
Polyklonal
Konjugat
Dieser LRP5 Antikörper ist unkonjugiert
8
7
7
5
5
5
4
4
4
3
3
3
2
2
2
2
2
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
66
46
31
29
10
3
3
3
2
2
1
1
Optionen
Immunogen Recombinant protein of human LRP5
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung LRP5 (LRP5 Antibody Abstract)
Hintergrund

Synonyms: BMND1,EVR1,EVR4,HBM,Low density lipoprotein receptor related protein 5,Low density lipoprotein receptor related protein 7,Low-density lipoprotein receptor-related protein 5,LR3,LRP-5,Lrp5,LRP5,LRP7,OPPG,OPS,OPTA1,Osteoporosis pseudoglioma syndrome,VBCH2

Background: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 150kDa

Calculated_MW: 179kDa

Gen-ID 4041
UniProt O75197
Pathways WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) antibody (ABIN6566477) Western blot analysis of extracts of various cell lines, using LRP5 antibody.
Image no. 2 for anti-Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) antibody (ABIN6566477) Immunohistochemistry of paraffin-embedded mouse lung using LRP5 antibody.
Image no. 3 for anti-Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) antibody (ABIN6566477) Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody.