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CYP27B1 Antikörper (C-Term)

CYP27B1 Reaktivität: Human, Ratte WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB16978 unconjugated
Produktnummer ABIN652999
  • Target Alle CYP27B1 Antikörper anzeigen
    CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
    Bindungsspezifität
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 482-508, C-Term
    Reaktivität
    • 15
    • 9
    • 7
    • 4
    Human, Ratte
    Wirt
    • 28
    • 2
    Kaninchen
    Klonalität
    • 28
    • 2
    Polyklonal
    Konjugat
    • 15
    • 5
    • 5
    • 4
    • 1
    Dieser CYP27B1 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 18
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1.
    Klon
    RB16978
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:500. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Chiang, Yeh, Huang, Yeh, S Pang, Hsu, Chen, Kuo, Kittaka, Chen, Juang: "25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)₂D₃." in: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).

    Schlosser, Carroll, Soler, Pasquini, Mulligan: "Reduced sinonasal levels of 1?-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps." in: International forum of allergy & rhinology, (2015) (PubMed).

    Mandell, Seedorf, Ryan, Gien, Cramer, Abman: "Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1?-hydroxylase expression in the developing rat." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L1018-26, (2015) (PubMed).

    Mulligan, Nagel, OConnell, Wentzel, Atkinson, Schlosser: "Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 2, pp. 342-349.e1, (2014) (PubMed).

  • Target
    CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
    Andere Bezeichnung
    CYP27B1 (CYP27B1 Produkte)
    Synonyme
    cp2b antikoerper, cyp1 antikoerper, cyp1alpha antikoerper, cyp27b antikoerper, p450c1 antikoerper, pddr antikoerper, vdd1 antikoerper, vddr antikoerper, vddri antikoerper, vdr antikoerper, CP2B antikoerper, CYP1 antikoerper, CYP1alpha antikoerper, CYP27B antikoerper, P450c1 antikoerper, PDDR antikoerper, VDD1 antikoerper, VDDR antikoerper, VDDRI antikoerper, VDR antikoerper, Cyp40 antikoerper, Cp2b antikoerper, Cyp1 antikoerper, Cyp27b antikoerper, Pddr antikoerper, Vdd1 antikoerper, Vddr antikoerper, VddrI antikoerper, Vdr antikoerper, cytochrome P450 family 27 subfamily B member 1 antikoerper, cytochrome P450, family 27, subfamily B, polypeptide 1 antikoerper, cytochrome P450, family 27, subfamily b, polypeptide 1 antikoerper, cyp27b1 antikoerper, CYP27B1 antikoerper, Cyp27b1 antikoerper
    Hintergrund
    CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
    Molekulargewicht
    56504
    Gen-ID
    1594
    NCBI Accession
    NP_000776
    UniProt
    O15528
    Pathways
    Metabolism of Steroid Hormones and Vitamin D
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