This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This CYP21A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the Central region of human CYP21A2.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
OShaughnessy, Monteiro, Bhattacharya, Fraser, Fowler: "Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy." in: Molecular human reproduction, Vol. 19, Issue 3, pp. 177-87, (2013) (PubMed).
Target
CYP21A2
(Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))
CA21H antikoerper, CAH1 antikoerper, CPS1 antikoerper, CYP21 antikoerper, CYP21B antikoerper, P450c21B antikoerper, 21-OH antikoerper, 21OH antikoerper, 21OHA antikoerper, 21OHB antikoerper, CYP21OH-A antikoerper, Cyp21 antikoerper, Cyp21-ps1 antikoerper, Cyp21B antikoerper, Cyp21a2-ps antikoerper, Cyp21a2ps antikoerper, Oh21-1 antikoerper, Oh21-2 antikoerper, CYP21A antikoerper, 21-OHase antikoerper, cytochrome P450 family 21 subfamily A member 2 antikoerper, cytochrome P450, family 21, subfamily a, polypeptide 1 antikoerper, cytochrome P450c21 antikoerper, cytochrome P450, family 21, subfamily A, polypepide 2 antikoerper, cytochrome P450, family 21, subfamily A, polypeptide 2 antikoerper, steroid 21-hydroxylase-like antikoerper, CYP21A2 antikoerper, Cyp21a1 antikoerper, LOC101094596 antikoerper
Hintergrund
CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in CYP21A2 gene cause congenital adrenal hyperplasia.