PTPN1 Antikörper
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- Target Alle PTPN1 Antikörper anzeigen
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTPN1 Antikörper ist unkonjugiert
- Applikation
- Bitte anfragen
- Verwendungszweck
- Rabbit Anti-PTP1B Antibody
- Immunogen
- This PTP1B antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B.
- Top Product
- Discover our top product PTPN1 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- Target
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- Andere Bezeichnung
- PTP1B (PTPN1 Produkte)
- Synonyme
- PTPN1 antikoerper, PTP1B antikoerper, PTP-1B antikoerper, PTP-HA2 antikoerper, Ptp antikoerper, ptp1b antikoerper, wu:fk54h03 antikoerper, CPTP1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 L homeolog antikoerper, PTPN1 antikoerper, Ptpn1 antikoerper, ptpn1 antikoerper, ptpn1.L antikoerper
- Hintergrund
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Target Description: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
Gene Symbol: PTPN1
- Gen-ID
- 5770
- UniProt
- P18031
- Pathways
- TLR Signalweg, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
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