HLA-DQA1 Antikörper

Produktnummer ABIN6297784

Produktdetails anti-HLA-DQA1 Antikörper

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Reaktivität: Human, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-DQA1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Verwendungszweck: Mouse anti-Human/Pig HLA-DQ Antibody (MHC II) [Sodium Azide Free]

Spezifität: Cell surface

Aufreinigung: The T4-positive CTL clone HG-38 was used as the immunogen for the HLA-DQ antibody.

Immunogen: The T4-positive CTL clone HG-38 was used as the immunogen for the HLA-DQ antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu HLA-DQA1

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Andere Bezeichnung: HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1 Produkte)

Synonyme: CD antikoerper, CELIAC1 antikoerper, DQ-A1 antikoerper, GSE antikoerper, HLA-DQA antikoerper, BoLA-DQA antikoerper, hla-dqa1 antikoerper, major histocompatibility complex, class II, DQ alpha 1 antikoerper, major histocompatibility complex, class II, DQ alpha, type 1 antikoerper, major histocompatibility complex, class II, DQ alpha 1 L homeolog antikoerper, HLA-DQA1 antikoerper, BOLA-DQA1 antikoerper, hla-dqa1.L antikoerper

Hintergrund:

Target Description: Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Gene Symbol: HLA-DQA1///HLA-DQB1///HLA-DQB

UniProt: P01909, P01920

Pathways: T-Zell Rezeptor Signalweg, Cancer Immune Checkpoints