C-Type Lectin Domain Family 4, Member M (CLEC4M) Antikörper

Produktnummer ABIN6291842

Produktdetails

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human CLEC4M

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node, Found in placental endothelium but not in macrophages, Expressed in type II alveolar cells and lung endothelial cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Antigendetails

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Andere Bezeichnung: CLEC4M (CLEC4M Produkte)

Synonyme: CD209L antikoerper, CD299 antikoerper, DC-SIGN2 antikoerper, DC-SIGNR antikoerper, DCSIGNR antikoerper, HP10347 antikoerper, L-SIGN antikoerper, LSIGN antikoerper, CD209B antikoerper, C-type lectin domain family 4 member M antikoerper, CLEC4M antikoerper

Hintergrund: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835, often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Molekulargewicht: 45.35 kDa

Gen-ID: 10332

UniProt: Q9H2X3