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PI3K p85/p55 Antikörper (pTyr199, pTyr467)

PI3K p85/p55 Reaktivität: Human, Maus, Ratte, Affe ELISA, IF, WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6288345
  • Target Alle PI3K p85/p55 Produkte
    PI3K p85/p55 (Phosphoinositide 3 Kinase, p85/p55 (PI3K p85/p55))
    Bindungsspezifität
    AA 410-490, pTyr199, pTyr467
    Reaktivität
    Human, Maus, Ratte, Affe
    Wirt
    • 8
    Kaninchen
    Klonalität
    • 8
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PI3K p85/p55 Antikörper ist unkonjugiert
    Applikation
    ELISA, Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    PI 3-kinase p85/p55 is a protein encoded by the PIK3R1 gene which is approximately 83,5 kDa. PI 3-kinase p85/p55 is localised to the cytoplasm, nucleus and cis-Golgi network. It is involved in RET signalling, IL-2 pathway, downstream signalling of activated FGFR2, regulation of lipid metabolism and insulin signalling-generic cascades. PI 3-Kinases are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival. PI 3-kinase p85/p55 is expressed in the nervous system, muscle, liver, heart and kidney. Mutations in the PIK3R1 gene may result in Agammaglobulinemia and SHORT syndrome. STJ90384 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous PI 3-kinase p85/p55 protein which only binds about Y467/199 when Y467/199 is phosphorylated.
    Spezifität
    Phospho-PI 3-kinase p85/p55 (Y467/199) Polyclonal Antibody detects endogenous levels of PI 3-kinase p85/p55 protein only when phosphorylated at Y467/199.
    Produktmerkmale
    Rabbit polyclonal to Phospho-PI 3-kinase p85/p55 (Y467/199).
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized peptide derived from human PI 3-kinase p85/p55 around the phosphorylation site of Y467/199.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
    Kommentare

    Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C, and avoid repeat freeze-thaw cycles.
  • Target
    PI3K p85/p55 (Phosphoinositide 3 Kinase, p85/p55 (PI3K p85/p55))
    Andere Bezeichnung
    PI 3-kinase p85/p55 (PI3K p85/p55 Produkte)
    Molekulargewicht
    54/83 kDa
    Gen-ID
    5295
    UniProt
    P27986
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