FZD2 Antikörper (Internal Region)
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- Target Alle FZD2 Antikörper anzeigen
- FZD2 (Frizzled Family Receptor 2 (FZD2))
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Bindungsspezifität
- AA 180-260, Internal Region
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FZD2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Verwendungszweck
- Frizzled-2 is a protein encoded by the FZD2 gene which is approximately 63,5 kDa. Frizzled-2 is localised to the cell membrane and is involved in CDK-mediated phosphorylation and removal of Cdc6, Wnt signalling pathway and pluripotency and mTOR signalling pathway. It is a receptor for Wnt proteins and is coupled to the beta-catenin canonical signalling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Frizzled-2 is widely expressed, it is mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. Mutations in the FZD2 gene result in omodysplasia. STJ93141 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Frizzled-2 protein.
- Spezifität
- Frizzled-2 Polyclonal Antibody detects endogenous levels of Frizzled-2 protein.
- Produktmerkmale
- Rabbit polyclonal to Frizzled-2.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human Frizzled-2
- Isotyp
- IgG
- Top Product
- Discover our top product FZD2 Primärantikörper
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- Applikationshinweise
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WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000 - Kommentare
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Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- Andere Bezeichnung
- Frizzled-2 (FZD2 Produkte)
- Synonyme
- BG01711 antikoerper, CG9739 antikoerper, D-Fz2 antikoerper, D-fz2 antikoerper, DFZ2 antikoerper, DFz-2 antikoerper, DFz2 antikoerper, Dfrz2 antikoerper, Dfz2 antikoerper, Dfz[[2]] antikoerper, Dm Fz2 antikoerper, Dmel\\CG9739 antikoerper, FZ2 antikoerper, Fz2 antikoerper, dFz2 antikoerper, dfz(2) antikoerper, dfz2 antikoerper, dfz2r antikoerper, frz2 antikoerper, fz-2 antikoerper, fz8 antikoerper, zfz2 antikoerper, zg08 antikoerper, cb383 antikoerper, wu:fb70g09 antikoerper, FZD2 antikoerper, fzE2 antikoerper, hFz2 antikoerper, Fz-10 antikoerper, Fzd10 antikoerper, cFz-2 antikoerper, frizzled2 antikoerper, fz2 antikoerper, xfz2 antikoerper, AL033370 antikoerper, AW456835 antikoerper, Fz10 antikoerper, Mfz10 antikoerper, Mfz10a antikoerper, frizzled 2 antikoerper, frizzled class receptor 2 antikoerper, frizzled class receptor 2 S homeolog antikoerper, fz2 antikoerper, fzd2 antikoerper, FZD2 antikoerper, Fzd2 antikoerper, fzd2.S antikoerper
- Molekulargewicht
- 55 kDa
- Gen-ID
- 2535
- UniProt
- Q14332
- Pathways
- WNT Signalweg
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