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LAT Antikörper (Linker For Activation of T Cells) (pTyr161) Primary Antibody

LAT Reaktivität: Human, Maus ELISA, ICC, IF, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6271566
$450.00
Zzgl. Versandkosten $45.00
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 8 bis 9 Werktagen
  • Target
    LAT
    Bindungsspezifität
    pTyr161
    • 17
    • 17
    • 14
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reaktivität
    Human, Maus
    • 128
    • 80
    • 78
    • 1
    Wirt
    Kaninchen
    • 113
    • 9
    • 7
    • 2
    Klonalität
    Polyklonal
    • 123
    • 8
    Konjugat
    Dieser LAT Antikörper ist unkonjugiert
    • 70
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Applikation
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    • 83
    • 46
    • 28
    • 16
    • 12
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    Spezifität
    LAT (Phospho-Tyr161) Antibody detects endogenous levels of LAT only when phosphorylated at Tyr161
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human LAT (Phospho-Tyr161)
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    LAT
    Andere Bezeichnung
    LAT (LAT Antibody Abstract)
    Synonyme
    LAT, lat, LAT1, pp36, linker for activation of T-cells, linker for activation of T cells, LAT, lat, Lat
    Hintergrund

    Description: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

    Gene: LAT

    Molekulargewicht
    28kDa
    Gen-ID
    27040
    UniProt
    O43561
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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