Neurofibromin 2 (NF2) (pSer13) Antikörper

Details zu Produkt Nr. ABIN6270005
Target
Bindungsspezifität
pSer13
28
15
14
10
8
7
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
116
81
72
10
6
4
4
4
4
3
3
3
1
Wirt
Kaninchen
109
7
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
8
6
5
5
5
5
5
4
4
2
2
2
2
2
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
70
43
32
25
20
14
6
6
4
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human Merlin around the phosphorylation site of Ser13
Isotyp IgG
Spezifität Phospho-Merlin (Ser13) Antibody detects endogenous levels of Merlin only when phosphorylated at Ser13
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Merlin (NF2 Antibody Abstract)
Hintergrund

Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Gene: NF2

Molekulargewicht 70kDa
Gen-ID 4771
UniProt P35240
Pathways Cell-Cell Junction Organization
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Neurofibromin 2 (NF2) (pSer13) antibody (ABIN6270005) Western blot analysis of Phospho-Merlin (Ser13) in lysates of NIH-3T3 IFN 2500U/ml 30...