Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (pTyr177) Antikörper

Details zu Produkt Nr. ABIN6270003
Target
Bindungsspezifität
pTyr177
14
8
7
7
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
110
63
43
7
5
5
3
3
3
3
3
Wirt
Kaninchen
70
32
8
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
4
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
81
40
32
31
25
14
13
5
3
2
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human CTNNA1 around the phosphorylation site of Tyr177
Isotyp IgG
Spezifität Phospho-CTNNA1 (Tyr177) Antibody detects endogenous levels of CTNNA1 only when phosphorylated at Tyr177
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung CTNNA1 (CTNNA1 Antibody Abstract)
Hintergrund

Description: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Gene: CTNNA1

Molekulargewicht 100kDa
Gen-ID 1495
UniProt P35221
Pathways Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (pTyr177) antibody (ABIN6270003) Western blot analysis of Phospho-CTNNA1 (Tyr177) in lysates of HeLa?, using Phospho-C...