AXL Antikörper (AXL Receptor tyrosine Kinase) (pTyr703)

Details for Product anti-AXL Antibody No. ABIN6269999
Target
Bindungsspezifität
pTyr703
20
19
17
17
15
15
11
11
9
9
7
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
166
78
59
5
2
2
1
1
1
1
Wirt
Kaninchen
150
26
3
1
Klonalität
Polyklonal
Konjugat
Dieser AXL Antikörper ist unkonjugiert
15
10
8
8
8
7
6
5
5
5
5
5
2
2
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
117
91
52
29
26
18
8
7
5
4
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human AXL around the phosphorylation site of Tyr703
Isotyp IgG
Spezifität Phospho-AXL (Tyr703) Antibody detects endogenous levels of AXL only when phosphorylated at Tyr703
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung AXL (AXL Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

Gene: AXL

Molekulargewicht 97.4kDa
Gen-ID 558
UniProt P30530
Pathways RTK Signalweg, Cellular Response to Molecule of Bacterial Origin
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-AXL Receptor tyrosine Kinase (AXL) (pTyr703) antibody (ABIN6269999) ABIN6270000 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Image no. 2 for anti-AXL Receptor tyrosine Kinase (AXL) (pTyr703) antibody (ABIN6269999) Western blot analysis of Phospho-AXL (Tyr703) in lysates of HuvEc EGF 200ng/ml 15', u...