PTPN6 Antikörper (Protein-tyrosine Phosphatase 1C) (pSer534)

Details for Product anti-PTPN6 Antibody No. ABIN6269987
Target
Bindungsspezifität
pSer534
31
7
7
7
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
117
44
40
3
2
2
2
2
1
1
1
1
Wirt
Kaninchen
90
21
7
Klonalität
Polyklonal
Konjugat
Dieser PTPN6 Antikörper ist unkonjugiert
10
6
5
4
4
4
4
4
4
3
2
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
79
45
31
17
14
14
13
12
5
4
3
2
2
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human SHP-1 around the phosphorylation site of Ser534
Isotyp IgG
Spezifität Phospho-SHP-1 (Ser534) Antibody detects endogenous levels of SHP-1 only when phosphorylated at Ser534
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SHP-1 (PTPN6 Antibody Abstract)
Hintergrund

Description: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Gene: PTPN6

Molekulargewicht 67kDa
Gen-ID 5777
UniProt P29350
Pathways JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pSer534) antibody (ABIN6269987) ABIN6269988 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...
Image no. 2 for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pSer534) antibody (ABIN6269987) Western blot analysis of Phospho-SHP-1 (Ser534) in lysates of RAW264.7 , using Phosph...
Image no. 3 for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pSer534) antibody (ABIN6269987) ABIN6269988 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Image no. 4 for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pSer534) antibody (ABIN6269987) ABIN6269988 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...