EPH Receptor A3 Antikörper (EPHA3) (pTyr596)

Details for Product anti-EPHA3 Antibody No. ABIN6269983
Target
Bindungsspezifität
pTyr596
20
16
15
14
10
10
9
9
7
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
126
60
51
13
6
5
3
2
2
2
2
1
Wirt
Kaninchen
120
9
1
Klonalität
Polyklonal
Konjugat
Dieser EPH Receptor A3 Antikörper ist unkonjugiert
10
6
6
6
6
6
6
5
5
4
4
4
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
85
60
46
15
13
5
2
2
2
2
2
Optionen
Immunogen A synthesized peptide derived from human EPHA3 around the phosphorylation site of Tyr596
Isotyp IgG
Spezifität Phospho-EPHA3 (Tyr596) Antibody detects endogenous levels of EPHA3 only when phosphorylated at Tyr596
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung EPHA3 (EPHA3 Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Gene: EPHA3

Molekulargewicht 120kDa
Gen-ID 2042
UniProt P29320
Pathways RTK Signalweg, Regulation of Cell Size
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-EPH Receptor A3 (EPHA3) (pTyr596) antibody (ABIN6269983) ABIN6269984 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-EPH Receptor A3 (EPHA3) (pTyr596) antibody (ABIN6269983) ABIN6269984 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...
Image no. 3 for anti-EPH Receptor A3 (EPHA3) (pTyr596) antibody (ABIN6269983) Western blot analysis of Phospho-EPHA3 (Tyr596) in lysates of HEK293 treated with per...