EPH Receptor A2 Antikörper (EPHA2) (pTyr772)

Details for Product anti-EPHA2 Antibody No. ABIN6269977
Target
Bindungsspezifität
pTyr772
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Reaktivität
Human, Maus
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Wirt
Kaninchen
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Klonalität
Polyklonal
Konjugat
Dieser EPH Receptor A2 Antikörper ist unkonjugiert
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Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
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Optionen
Immunogen A synthesized peptide derived from human EPHA2 around the phosphorylation site of Tyr772
Isotyp IgG
Spezifität Phospho-EPHA2 (Tyr772) Antibody detects endogenous levels of EPHA2 only when phosphorylated at Tyr772
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung EPHA2 (EPHA2 Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Gene: EPHA2

Molekulargewicht 105kDa
Gen-ID 1969
UniProt P29317
Pathways RTK Signalweg
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-EPH Receptor A2 (EPHA2) (pTyr772) antibody (ABIN6269977) ABIN6269978 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...
Image no. 2 for anti-EPH Receptor A2 (EPHA2) (pTyr772) antibody (ABIN6269977) Western blot analysis of Phospho-EPHA2 (Tyr772) in lysates of NIH/3T3?, using Phospho...