Phospholamban Antikörper (PLN) (pSer16)

Details for Product anti-PLN Antibody No. ABIN6269969
Target
Bindungsspezifität
pSer16, pThr17
27
17
10
9
5
3
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
87
62
56
4
4
3
2
Wirt
Kaninchen
87
7
3
Klonalität
Polyklonal
Konjugat
Dieser Phospholamban Antikörper ist unkonjugiert
9
6
6
5
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
33
33
26
17
13
10
8
7
6
4
2
2
1
Optionen
Immunogen A synthesized peptide derived from human Phospholamban around the phosphorylation site of Ser16/Thr17
Isotyp IgG
Spezifität Phospho-Phospholamban (Ser16/Thr17) Antibody detects endogenous levels of Phospholamban only when phosphorylated at Ser16/Thr17
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Phospholamban (PLN Antibody Abstract)
Hintergrund

Description: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Gene: PLN

Molekulargewicht 24kDa
Gen-ID 5350
UniProt P26678
Pathways Negative Regulation of Transporter Activity
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Phospholamban (PLN) (pSer16), (pThr17) antibody (ABIN6269969) Western blot analysis of extracts of mouse heart tissue sample,using Phospho-Phosphol...