Cofilin 1 (CFL1) (pTyr140) Antikörper

Details zu Produkt Nr. ABIN6269945
Target
  • cfl1
  • xac1
  • xac2
  • cfl
  • cb86
  • sb:cb86
  • zgc:56501
  • wu:fb18a04
  • wu:fk77b03
  • 12/8
  • ADF
  • ADF/cofilin
  • Adf
  • CG4254
  • Cadf
  • D-cof
  • D61
  • Dmel\\CG4254
  • T8
  • Tsr
  • cofilin
  • cofilin/ADF
  • cofilin/actin depolymerizing factor homolog
  • l(2)03101
  • l(2)k03101
  • l(2)k05633
  • l(2)k13409
  • ntf
  • CFL
  • AA959946
  • Cof
  • CFL1
  • cofilin 1 (non-muscle) L homeolog
  • cofilin 1 (non-muscle)
  • cofilin 1 (non-muscle), like
  • cofilin 1
  • twinstar
  • cofilin
  • cofilin 1, non-muscle
  • Contrafreeloading
  • cfl1.L
  • cfl1
  • cfl1l
  • CFL1
  • tsr
  • COF1
  • TSTA_042790
  • Cfl1
  • CFL
Bindungsspezifität
pTyr140
23
22
16
15
15
13
10
9
8
7
7
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
192
126
105
11
11
9
7
2
2
2
1
1
Wirt
Kaninchen
171
21
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
14
10
8
6
6
6
5
4
4
4
4
4
2
2
2
2
2
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
132
92
73
38
30
28
25
17
9
6
5
4
4
3
3
2
Optionen
Immunogen A synthesized peptide derived from human Cofilin around the phosphorylation site of Tyr140
Isotyp IgG
Spezifität Phospho-Cofilin (Tyr140) Antibody detects endogenous levels of Cofilin only when phosphorylated at Tyr140
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Cofilin (CFL1 Antibody Abstract)
Hintergrund

Description: Binds to F-actin and exhibits  pH -sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

Gene: CFL1

Molekulargewicht 19kDa
Gen-ID 1072
UniProt P23528
Pathways Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Cofilin 1 (CFL1) (pTyr140) antibody (ABIN6269945) Western blot analysis of Phospho-Cofilin (Tyr140) in lysates of COLO205 , using Phosp...
Image no. 2 for anti-Cofilin 1 (CFL1) (pTyr140) antibody (ABIN6269945) ABIN6269946 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...
Image no. 3 for anti-Cofilin 1 (CFL1) (pTyr140) antibody (ABIN6269945) ABIN6269946 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...