CBL Antikörper (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (pSer804)

Details for Product anti-CBL Antibody No. ABIN6269939
Target
Bindungsspezifität
pSer804
28
27
25
23
16
8
7
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
218
164
154
4
2
1
1
Wirt
Kaninchen
191
21
7
1
Klonalität
Polyklonal
Konjugat
Dieser CBL Antikörper ist unkonjugiert
14
11
8
8
8
8
8
8
8
5
5
5
5
5
4
4
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
129
65
60
59
34
33
19
11
9
7
3
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human CBL around the phosphorylation site of Ser804
Isotyp IgG
Spezifität Phospho-CBL (Ser804) Antibody detects endogenous levels of CBL only when phosphorylated at Ser804
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung CBL (CBL Antibody Abstract)
Hintergrund

Description: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Gene: CBL

Molekulargewicht 120kDa
Gen-ID 867
UniProt P22681
Pathways T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pSer804) antibody (ABIN6269939) ABIN6269940 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pSer804) antibody (ABIN6269939) ABIN6269940 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...
Image no. 3 for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pSer804) antibody (ABIN6269939) Western blot analysis of Phospho-CBL (Ser804) in lysates of HeLa EGF 200ng/ml 30', us...