FGFR4 Antikörper (Fibroblast Growth Factor Receptor 4) (pTyr642)

Details for Product anti-FGFR4 Antibody No. ABIN6269937
Target
Bindungsspezifität
pTyr642
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Reaktivität
Human, Maus, Ratte
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44
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2
1
Wirt
Kaninchen
93
26
Klonalität
Polyklonal
Konjugat
Dieser FGFR4 Antikörper ist unkonjugiert
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Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
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Optionen
Immunogen A synthesized peptide derived from human FGFR4 around the phosphorylation site of Tyr642
Isotyp IgG
Spezifität Phospho-FGFR4 (Tyr642) Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr642
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FGFR4 (FGFR4 Antibody Abstract)
Hintergrund

Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Gene: FGFR4

Molekulargewicht 87.9kDa
Gen-ID 2264
UniProt P22455
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (pTyr642) antibody (ABIN6269937) ABIN6269938 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (pTyr642) antibody (ABIN6269937) Western blot analysis of Phospho-FGFR4 (Tyr642) in lysates of Jurkat, using Phospho-F...