ERBB3 Antikörper (Receptor Tyrosine-Protein Kinase ErbB-3) (pTyr1197)

Details for Product anti-ERBB3 Antibody No. ABIN6269933
Target
  • ErbB-3
  • HER3
  • LCCS2
  • MDA-BF-1
  • c-erbB-3
  • c-erbB3
  • erbB3-S
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • ERBB3
  • C76256
  • Erbb-3
  • Erbb3r
  • Her3
  • nuc-ErbB3
  • erb-b2 receptor tyrosine kinase 3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • ERBB3
  • Erbb3
Bindungsspezifität
pTyr1197
25
22
22
16
16
15
15
15
15
15
13
10
8
8
7
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
301
165
143
8
4
3
3
3
2
2
2
2
1
1
1
Wirt
Kaninchen
234
70
10
1
Klonalität
Polyklonal
Konjugat
Dieser ERBB3 Antikörper ist unkonjugiert
20
13
10
10
10
10
10
10
8
5
5
5
5
5
5
5
3
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
167
115
86
67
61
57
44
34
9
9
6
6
3
3
3
2
1
Optionen
Immunogen A synthesized peptide derived from human HER3/ErbB3 around the phosphorylation site of Tyr1197
Isotyp IgG
Spezifität Phospho-HER3/ErbB3 (Tyr1197) Antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at Tyr1197
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung HER3/ErbB3 (ERBB3 Antibody Abstract)
Hintergrund

Description: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).

Gene: ERBB3

Molekulargewicht 148kDa
Gen-ID 2065
UniProt P21860
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1197) antibody (ABIN6269933) ABIN6269934 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Image no. 2 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1197) antibody (ABIN6269933) Western blot analysis of Phospho-HER3/ErbB3 (Tyr1197) in lysates of HuvEc EGF 200ng/m...
Image no. 3 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1197) antibody (ABIN6269933) ABIN6269934 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 4 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1197) antibody (ABIN6269933) ABIN6269934 at 1/100 staining human lung cancer tissue sections by IHC-P. The tissue ...