ERBB3 Antikörper (Receptor Tyrosine-Protein Kinase ErbB-3) (pSer684)

Details for Product anti-ERBB3 Antibody No. ABIN6269931
Target
  • ErbB-3
  • HER3
  • LCCS2
  • MDA-BF-1
  • c-erbB-3
  • c-erbB3
  • erbB3-S
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • ERBB3
  • C76256
  • Erbb-3
  • Erbb3r
  • Her3
  • nuc-ErbB3
  • erb-b2 receptor tyrosine kinase 3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • ERBB3
  • Erbb3
Bindungsspezifität
pSer684
24
22
20
16
16
15
15
15
15
14
11
10
8
7
7
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
288
156
135
8
4
3
3
3
2
2
2
2
1
1
1
Wirt
Kaninchen
224
67
10
1
Klonalität
Polyklonal
Konjugat
Dieser ERBB3 Antikörper ist unkonjugiert
20
13
10
10
10
10
10
10
8
5
5
5
5
5
5
5
3
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
155
104
78
67
61
48
38
34
9
6
6
5
3
3
3
2
1
Optionen
Immunogen A synthesized peptide derived from human HER3 around the phosphorylation site of Ser684
Isotyp IgG
Spezifität Phospho-HER3 (Ser684) Antibody detects endogenous levels of HER3 only when phosphorylated at Ser684
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung HER3 (ERBB3 Antibody Abstract)
Hintergrund

Description: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).

Gene: ERBB3

Molekulargewicht 148kDa
Gen-ID 2065
UniProt P21860
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pSer684) antibody (ABIN6269931) Western blot analysis of Phospho-HER3 (Ser684) in lysates of HuvEc EGF 200ng/ml 30', ...
Image no. 2 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pSer684) antibody (ABIN6269931) ABIN6269932 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Image no. 3 for anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pSer684) antibody (ABIN6269931) ABIN6269932 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...