Phospholipase C gamma 1 Antikörper (phospholipase C, gamma 1) (pTyr977)

Details for Product anti-PLCG1 Antibody No. ABIN6269919
Target
Bindungsspezifität
pTyr977
33
25
15
9
8
7
7
6
5
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
184
145
141
33
13
7
6
4
3
2
1
1
Wirt
Kaninchen
156
29
Klonalität
Polyklonal
Konjugat
Dieser Phospholipase C gamma 1 Antikörper ist unkonjugiert
10
10
8
8
8
8
8
3
2
2
2
2
2
2
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
121
61
51
29
27
20
20
16
14
7
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human PLCG1 around the phosphorylation site of Tyr977
Isotyp IgG
Spezifität Phospho-PLCG1 (Tyr977) Antibody detects endogenous levels of PLCG1 only when phosphorylated at Tyr977
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PLCG1 (PLCG1 Antibody Abstract)
Hintergrund

Description: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Gene: PLCG1

Molekulargewicht 155kDa
Gen-ID 5335
UniProt P19174
Pathways RTK Signalweg, WNT Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-phospholipase C, gamma 1 (PLCG1) (pTyr977) antibody (ABIN6269919) Western blot analysis of Phospho-PLCG1 (Tyr977) in lysates of COS7 EGF 200ng/ml 30', ...