CEBPB Antikörper (CCAAT/enhancer Binding Protein (C/EBP), beta) (pSer76)

Details for Product anti-CEBPB Antibody No. ABIN6269907
Target
Bindungsspezifität
pSer76
16
14
10
7
6
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
106
77
70
13
10
5
5
3
1
1
1
Wirt
Kaninchen
105
22
7
1
Klonalität
Polyklonal
Konjugat
Dieser CEBPB Antikörper ist unkonjugiert
8
5
5
5
5
5
5
3
3
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
96
49
38
25
13
10
10
8
7
6
3
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human C/EBPbeta around the phosphorylation site of Ser76
Isotyp IgG
Spezifität Phospho-C/EBPbeta (Ser76) Antibody detects endogenous levels of C/EBPbeta only when phosphorylated at Ser76
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung C/EBPbeta (CEBPB Antibody Abstract)
Hintergrund

Description: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1, represses expression of DSPP during odontoblast differentiation (By similarity).

Gene: CEBPB

Molekulargewicht 36kDa
Gen-ID 1051
UniProt P17676
Pathways Interferon-gamma Pathway, Autophagie, Brown Fat Cell Differentiation
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB) (pSer76) antibody (ABIN6269907) Western blot analysis of Phospho-C/EBPbeta (Ser76) in lysates of HepG2 EGF 200ng/ml 3...