FER Tyrosine Kinase (FER) (pTyr497) Antikörper

Details zu Produkt Nr. ABIN6269887
Target
Bindungsspezifität
pTyr497
22
22
8
7
7
6
6
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
101
88
52
10
6
6
3
2
1
1
Wirt
Kaninchen
104
10
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
8
6
6
4
4
4
4
4
4
4
4
4
2
2
2
2
2
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
80
47
26
23
15
13
7
6
2
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human FER around the phosphorylation site of Tyr497
Isotyp IgG
Spezifität Phospho-FER (Tyr497) Antibody detects endogenous levels of FER only when phosphorylated at Tyr497
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FER (FER Antibody Abstract)
Hintergrund

Description: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Gene: FER

Molekulargewicht 95kDa
Gen-ID 2241
UniProt P16591
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-FER Tyrosine Kinase (FER) (pTyr497) antibody (ABIN6269887) ABIN6269888 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-FER Tyrosine Kinase (FER) (pTyr497) antibody (ABIN6269887) ABIN6269888 at 1/100 staining human gastric cancer tissue sections by IHC-P. The tiss...
Image no. 3 for anti-FER Tyrosine Kinase (FER) (pTyr497) antibody (ABIN6269887) ABIN6269888 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...