Pyruvate Kinase M1/2 (PKM) (pSer37) Antikörper

Details zu Produkt Nr. ABIN6269875
Target
Bindungsspezifität
pSer37
24
19
18
18
15
15
8
8
8
7
7
7
6
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
207
123
99
6
6
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
177
28
6
2
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
19
12
11
11
11
11
11
7
7
3
3
3
2
2
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
135
79
51
26
26
22
18
10
8
6
4
3
3
2
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human PKM2 around the phosphorylation site of Ser37
Isotyp IgG
Spezifität Phospho-PKM2(Ser37) Antibody detects endogenous levels of PKM2 only when phosphorylated at Ser37
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PKM2 (PKM Antibody Abstract)
Hintergrund

Description: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Gene: PKM

Molekulargewicht 60kDa
Gen-ID 5315
UniProt P14618
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Pyruvate Kinase M1/2 (PKM) (pSer37) antibody (ABIN6269875) ABIN6269876 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-Pyruvate Kinase M1/2 (PKM) (pSer37) antibody (ABIN6269875) ABIN6269876 at 1/100 staining human gastric cancer tissue sections by IHC-P. The tiss...
Image no. 3 for anti-Pyruvate Kinase M1/2 (PKM) (pSer37) antibody (ABIN6269875) Western blot analysis of Phospho-PKM2(Ser37) in lysates of 293T?, using Phospho-PKM2(...