APP Antikörper (Amyloid beta (A4) Precursor Protein) (pThr757)

Details for Product anti-APP Antibody No. ABIN6269789
Target
Bindungsspezifität
pThr757
56
36
28
25
25
16
15
13
12
12
11
10
9
9
9
8
8
7
7
7
7
6
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
500
218
201
38
17
16
13
12
12
11
11
7
5
4
2
2
2
1
1
1
1
Wirt
Kaninchen
353
139
21
8
1
Klonalität
Polyklonal
Konjugat
Dieser APP Antikörper ist unkonjugiert
46
34
33
13
13
12
11
11
11
10
10
9
9
9
9
9
8
3
3
2
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
329
240
161
110
66
50
45
41
20
20
14
11
6
4
3
2
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human APP around the phosphorylation site of Thr757
Isotyp IgG
Spezifität Phospho-APP (Thr757) Antibody detects endogenous levels of APP only when phosphorylated at Thr757
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund

Description: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

Gene: APP

Molekulargewicht 140kDa
Gen-ID 351
UniProt P05067
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Amyloid beta (A4) Precursor Protein (APP) (pThr757) antibody (ABIN6269789) ABIN6269790 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was form...
Image no. 2 for anti-Amyloid beta (A4) Precursor Protein (APP) (pThr757) antibody (ABIN6269789) ABIN6269790 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 3 for anti-Amyloid beta (A4) Precursor Protein (APP) (pThr757) antibody (ABIN6269789) ABIN6269790 at 1/100 staining mouse liver tissue sections by IHC-P. The tissue was fo...
Image no. 4 for anti-Amyloid beta (A4) Precursor Protein (APP) (pThr757) antibody (ABIN6269789) Western blot analysis of Phospho-APP (Thr757) in lysates of HeLa, using Phospho-APP (...