HER2 Antikörper (Receptor tyrosine-protein kinase erbB-2) (pTyr1023)

Details for Product anti-ErbB2/Her2 Antibody No. ABIN6269779
Target
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Bindungsspezifität
pTyr1023
54
45
37
30
28
27
26
26
22
22
18
15
14
11
10
10
10
10
10
9
9
9
9
9
8
8
8
8
8
8
8
8
7
7
7
7
7
5
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
621
291
236
22
15
9
6
6
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
Wirt
Kaninchen
492
186
11
7
6
2
2
1
Klonalität
Polyklonal
Konjugat
Dieser HER2 Antikörper ist unkonjugiert
55
37
28
25
24
21
16
15
15
14
14
14
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
318
303
179
155
140
128
81
62
57
23
18
18
12
8
7
6
6
3
2
1
1
1
1
1
1
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human HER2/ErbB2 around the phosphorylation site of Tyr1023
Isotyp IgG
Spezifität Phospho-HER2/ErbB2 (Tyr1023) Antibody detects endogenous levels of HER2/ErbB2 only when phosphorylated at Tyr1023
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung HER2/ErbB2 (ErbB2/Her2 Antibody Abstract)
Hintergrund

Description: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Gene: ERBB2

Molekulargewicht 138kDa
Gen-ID 2064
UniProt P04626
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1023) antibody (ABIN6269779) Western blot analysis of Phospho-HER2/ErbB2 (Tyr1023) in lysates of MDA-MB-231, using...
Image no. 2 for anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1023) antibody (ABIN6269779) ABIN6269780 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 3 for anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1023) antibody (ABIN6269779) ABIN6269780 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...