Lamin A/C Antikörper (LMNA) (pSer301)

Details for Product anti-LMNA Antibody No. ABIN6269771
Target
Bindungsspezifität
pSer301
20
13
13
12
10
9
8
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4
4
4
4
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3
2
2
2
2
2
2
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2
2
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2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
201
136
132
34
23
18
16
10
9
9
6
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4
4
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3
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
148
59
3
1
Klonalität
Polyklonal
Konjugat
Dieser Lamin A/C Antikörper ist unkonjugiert
8
7
6
3
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
172
79
65
56
50
39
31
26
25
14
10
9
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser301
Isotyp IgG
Spezifität Phospho-Lamin A/C (Ser301) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Ser301
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Lamin A/C (LMNA Antibody Abstract)
Hintergrund

Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).

Gene: LMNA

Molekulargewicht 74,65kDa
Gen-ID 4000
UniProt P02545
Pathways Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Lamin A/C (LMNA) (pSer301) antibody (ABIN6269771) Western blot analysis of Phospho-Lamin A/C (Ser301) in lysates of HeLa, using Phospho...