LATS1 Antikörper (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila)) (pThr1079)

Details for Product anti-LATS1 Antibody No. ABIN6269755
Target
Bindungsspezifität
pThr1079
18
17
15
10
8
8
4
4
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
80
54
35
3
3
3
2
2
2
1
1
1
1
Wirt
Kaninchen
78
3
Klonalität
Polyklonal
Konjugat
Dieser LATS1 Antikörper ist unkonjugiert
8
5
4
4
4
4
4
4
4
2
2
2
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
47
32
24
13
8
5
2
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human LATS1 around the phosphorylation site of Thr1079
Isotyp IgG
Spezifität Phospho-LATS1 (Thr1079) Antibody detects endogenous levels of LATS1 only when phosphorylated at Thr1079
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung LATS1
Hintergrund

Description: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).

Gene: LATS1

Molekulargewicht 160kDa
Gen-ID 9113
UniProt O95835
Pathways Regulation of Actin Filament Polymerization, Maintenance of Protein Location
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibody (ABIN6269755) ABIN6269756 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibody (ABIN6269755) ABIN6269756 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...
Image no. 3 for anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibody (ABIN6269755) Western blot analysis of Phospho-LATS1 (Thr1079) in lysates of A549 , using Phospho-L...