PAK3 (pSer186) Antikörper

Details zu Produkt Nr. ABIN6269735
Target
Bindungsspezifität
pSer186
15
14
10
10
9
7
7
5
4
3
2
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
102
58
44
3
Wirt
Kaninchen
96
7
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
9
6
6
4
4
4
4
4
4
4
4
4
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
75
55
48
13
10
4
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human PAK3 around the phosphorylation site of Ser186
Isotyp IgG
Spezifität Phospho-PAK3 (Ser186) Antibody detects endogenous levels of PAK3 only when phosphorylated at Ser186
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Hintergrund

Description: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Gene: PAK3

Molekulargewicht 72kDa
Gen-ID 5063
UniProt O75914
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-PAK3 (pSer186) antibody (ABIN6269735) Western blot analysis of extracts of rat heart tissue sample,using Phospho-PAK3 (Ser1...