Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (pTyr371) Antikörper

Details zu Produkt Nr. ABIN6269733
Target
Bindungsspezifität
pTyr371
14
11
11
9
7
7
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
78
33
16
Wirt
Kaninchen
68
7
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
3
3
3
3
3
3
3
3
3
3
3
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
64
38
16
12
5
4
3
2
2
1
Optionen
Immunogen A synthesized peptide derived from human STAM2 around the phosphorylation site of Tyr371
Isotyp IgG
Spezifität Phospho-STAM2 (Tyr371) Antibody detects endogenous levels of STAM2 only when phosphorylated at Tyr371
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung STAM2 (STAM2 Antibody Abstract)
Hintergrund

Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene: STAM2

Molekulargewicht 58kDa
Gen-ID 10254
UniProt O75886
Pathways EGFR Signaling Pathway, EGFR Downregulation
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (pTyr371) antibody (ABIN6269733) ABIN6269734 at 1/100 staining mouse brain tissue sections by IHC-P. The tissue was fo...
Image no. 2 for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (pTyr371) antibody (ABIN6269733) ABIN6269734 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 3 for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (pTyr371) antibody (ABIN6269733) Western blot analysis of Phospho-STAM2 (Tyr371) in lysates of NIH-3T3 EGF 200ng/ml 30...